The CYB5R4 Polyclonal Antibody (PACO8699) is a valuable tool for research involving CYB5R4, a protein involved in various cellular processes, including electron transfer and redox metabolism. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the CYB5R4 protein, researchers can accurately detect and analyze CYB5R4 expression in a variety of cell types, making it an ideal choice for studies in biochemistry and metabolic research.
CYB5R4, also known as cytochrome b5 reductase 4, plays a crucial role in maintaining cellular redox balance and electron transfer processes. Dysregulation of CYB5R4 has been implicated in various diseases, including metabolic disorders and cancer. Understanding the function and regulation of CYB5R4 is essential for developing targeted therapies and interventions aimed at restoring proper cellular function in these pathological contexts.
CYB5R4: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Protein type: Oxidoreductase; EC 1.6.2.2; Endoplasmic reticulum; Cell development/differentiationChromosomal Location of Human Ortholog: 6pter-q22.33Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulumMolecular Function: FAD binding; NADPH-hemoprotein reductase activity; NAD(P)H oxidase activity; cytochrome-b5 reductase activity; metal ion binding; oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor; heme bindingBiological Process: response to antibiotic; generation of precursor metabolites and energy; detection of oxygen; insulin secretion; superoxide metabolic process; glucose homeostasis; NADP metabolic process; cell development
UniProt Protein Details:
NCBI Summary:
NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010]
