UniProt Protein Function: | CYB5R4: NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.Protein type: Oxidoreductase; EC 1.6.2.2; Endoplasmic reticulum; Cell development/differentiationChromosomal Location of Human Ortholog: 6pter-q22.33Cellular Component: perinuclear region of cytoplasm; endoplasmic reticulumMolecular Function: FAD binding; NADPH-hemoprotein reductase activity; NAD(P)H oxidase activity; cytochrome-b5 reductase activity; metal ion binding; oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor; heme bindingBiological Process: response to antibiotic; generation of precursor metabolites and energy; detection of oxygen; insulin secretion; superoxide metabolic process; glucose homeostasis; NADP metabolic process; cell development |
UniProt Protein Details: | |
NCBI Summary: | NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010] |
UniProt Code: | Q7L1T6 |
NCBI GenInfo Identifier: | 121944420 |
NCBI Gene ID: | 51167 |
NCBI Accession: | Q7L1T6.1 |
UniProt Secondary Accession: | Q7L1T6,Q5TGI9, Q9NUE4, Q9UHI9, B1AEM2 |
UniProt Related Accession: | Q7L1T6 |
Molecular Weight: | |
NCBI Full Name: | Cytochrome b5 reductase 4 |
NCBI Synonym Full Names: | cytochrome b5 reductase 4 |
NCBI Official Symbol: | CYB5R4Â Â |
NCBI Official Synonym Symbols: | NCB5OR; cb5/cb5R; dJ676J13.1Â Â |
NCBI Protein Information: | cytochrome b5 reductase 4; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; NADPH cytochrome B5 oxidoreductase; cytochrome b-type NAD(P)H oxidoreductase; flavohemoprotein b5+b5R; flavohemoprotein b5/b5R |
UniProt Protein Name: | Cytochrome b5 reductase 4 |
UniProt Synonym Protein Names: | Flavohemoprotein b5/b5R; b5+b5R; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein; cb5/cb5R |
Protein Family: | Cytochrome |
UniProt Gene Name: | CYB5R4Â Â |
UniProt Entry Name: | NB5R4_HUMAN |