CYB5R3 Rabbit Polyclonal Antibody (CAB7535)
- SKU:
- CAB7535
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | CYB5R3 Rabbit Polyclonal Antibody |
SKU: | CAB7535 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 125-334 of human CYB5R3 (NP_001165131.1). |
Sequence: | RPYT PISS DDDK GFVD LVIK VYFK DTHP KFPA GGKM SQYL ESMQ IGDT IEFR GPSG LLVY QGKG KFAI RPDK KSNP IIRT VKSV GMIA GGTG ITPM LQVI RAIM KDPD DHTV CHLL FANQ TEKD ILLR PELE ELRN KHSA RFKL WYTL DRAP EAWD YGQG FVNE EMIR DHLP PPEE EPLV LMCG PPPM IQYA CLPN LDHV GHPT ERCF VF |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | B5R; DIA1; CYB5R3 |
Positive Sample: | HepG2,HeLa,HT-1080,NIH/3T3,Mouse kidney,Mouse brain,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Lipid-anchor, Mitochondrion outer membrane. |
Calculated MW: | 34kDa |
Observed MW: | 34-36kDa |
This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.
Purification Method: | Affinity purification |
Gene ID: | 1727 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |