CYB5R2 Antibody (PACO36670)
- SKU:
- PACO36670
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CYB5R2 Antibody (PACO36670)
The Cyb5R2 Polyclonal Antibody (PAC03670) is a vital tool for researchers studying Cyb5R2, a key enzyme involved in the electron transport chain. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications. By specifically binding to Cyb5R2, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in biochemistry and molecular biology.Cyb5R2, also known as cytochrome b5 reductase 2, plays a crucial role in electron transfer reactions within cells, ultimately contributing to various physiological processes such as metabolism and detoxification.
Its importance in cellular function highlights the significance of exploring its potential roles in disease states and drug metabolism. By elucidating the functions of Cyb5R2, researchers may uncover new therapeutic targets for conditions related to mitochondrial dysfunction and oxidative stress.
| Antibody Name: | CYB5R2 Antibody (PACO36670) |
| Antibody SKU: | PACO36670 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human NADH-cytochrome b5 reductase 2 protein (1-237AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CYB5R2 antibody at 4µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32, 28 kDa. Observed band size: 32 kDa. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO36670 at dilution of 1:100. |
| Background: | NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acid, , cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1). |
| Synonyms: | NADH-cytochrome b5 reductase 2 (b5R.2) (EC 1.6.2.2), CYB5R2 |
| UniProt Protein Function: | CYB5R2: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1). Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Oxidoreductase; EC 1.6.2.2 Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: endoplasmic reticulum membrane; membrane; nucleus Molecular Function:cytochrome-b5 reductase activity; protein binding Biological Process: bicarbonate transport |
| NCBI Summary: | The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
| UniProt Code: | Q6BCY4 |
| NCBI GenInfo Identifier: | 74709211 |
| NCBI Gene ID: | 51700 |
| NCBI Accession: | Q6BCY4.1 |
| UniProt Secondary Accession: | Q6BCY4,Q9BVA3, Q9UF68, Q9UHJ0, |
| UniProt Related Accession: | Q6BCY4 |
| Molecular Weight: | 27,043 Da |
| NCBI Full Name: | NADH-cytochrome b5 reductase 2 |
| NCBI Synonym Full Names: | cytochrome b5 reductase 2 |
| NCBI Official Symbol: | CYB5R2Â Â |
| NCBI Official Synonym Symbols: | B5R.2Â Â |
| NCBI Protein Information: | NADH-cytochrome b5 reductase 2 |
| UniProt Protein Name: | NADH-cytochrome b5 reductase 2 |
| Protein Family: | NADH-cytochrome b5 reductase |
| UniProt Gene Name: | CYB5R2Â Â |
| UniProt Entry Name: | NB5R2_HUMAN |
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