UniProt Protein Function: | CXXC5: May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding; sequence-specific DNA binding; signal transducer activity; transcription factor bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015] |
UniProt Code: | Q7LFL8 |
NCBI GenInfo Identifier: | 167011303 |
NCBI Gene ID: | 51523 |
NCBI Accession: | Q7LFL8.1 |
UniProt Secondary Accession: | Q7LFL8,Q8TB79, Q9NV51, Q9P0S8, B3KND0, C8CBA8 |
UniProt Related Accession: | Q7LFL8 |
Molecular Weight: | 24,072 Da |
NCBI Full Name: | CXXC-type zinc finger protein 5 |
NCBI Synonym Full Names: | CXXC finger protein 5 |
NCBI Official Symbol: | CXXC5Â Â |
NCBI Official Synonym Symbols: | CF5; WID; RINF; HSPC195Â Â |
NCBI Protein Information: | CXXC-type zinc finger protein 5 |
UniProt Protein Name: | CXXC-type zinc finger protein 5 |
UniProt Synonym Protein Names: | Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; Retinoid-inducible nuclear factor; RINF |
Protein Family: | CXXC-type zinc finger protein |
UniProt Gene Name: | CXXC5Â Â |
UniProt Entry Name: | CXXC5_HUMAN |