CXXC5 Antibody (PACO16092)
- SKU:
- PACO16092
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CXXC5 Antibody (PACO16092)
The CXXC5 Polyclonal Antibody (PAC016092) is a specialized tool for researchers studying the CXXC5 protein, an important regulator of gene expression and cellular processes. This antibody, generated in rabbits, shows high specificity for human samples and is validated for use in Western blot applications. By targeting the CXXC5 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential tool for investigations in the fields of molecular biology and cancer research.
CXXC5, also known as a transcriptional regulator, plays a crucial role in modulating gene expression and cellular functions, making it a key player in various biological processes. Its involvement in gene regulation makes CXXC5 a promising target for research in cancer biology, developmental biology, and stem cell research. Understanding the function of CXXC5 is essential for unveiling its potential implications in disease mechanisms and identifying new therapeutic targets for various conditions.
| Antibody Name: | CXXC5 Antibody (PACO16092) |
| Antibody SKU: | PACO16092 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human CXXC5 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16092(CXXC5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO16092(CXXC5 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16092(CXXC5 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | CXXC5 (CXXC finger 5), also known as RINF or HSPC195, is a 322 amino acid, protein that localizes to both the nucleus and the cytoplasm and contains one CXXC-type zinc finger. Interacting with Dvl-1, CXXC5 acts as a mediator of Wnt signaling in neural stem cells and is thought to participate in the activation of MAP kinase pathways. The gene encoding CXXC5 maps to human chromosome 5 and is expressed as multiple alternatively spliced isoforms. |
| Synonyms: | CXXC finger protein 5 |
| UniProt Protein Function: | CXXC5: May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytoplasm; nucleoplasmMolecular Function: protein binding; sequence-specific DNA binding; signal transducer activity; transcription factor bindingBiological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q7LFL8 |
| NCBI GenInfo Identifier: | 167011303 |
| NCBI Gene ID: | 51523 |
| NCBI Accession: | Q7LFL8.1 |
| UniProt Secondary Accession: | Q7LFL8,Q8TB79, Q9NV51, Q9P0S8, B3KND0, C8CBA8 |
| UniProt Related Accession: | Q7LFL8 |
| Molecular Weight: | 24,072 Da |
| NCBI Full Name: | CXXC-type zinc finger protein 5 |
| NCBI Synonym Full Names: | CXXC finger protein 5 |
| NCBI Official Symbol: | CXXC5Â Â |
| NCBI Official Synonym Symbols: | CF5; WID; RINF; HSPC195Â Â |
| NCBI Protein Information: | CXXC-type zinc finger protein 5 |
| UniProt Protein Name: | CXXC-type zinc finger protein 5 |
| UniProt Synonym Protein Names: | Putative MAPK-activating protein PM08; Putative NF-kappa-B-activating protein 102; Retinoid-inducible nuclear factor; RINF |
| Protein Family: | CXXC-type zinc finger protein |
| UniProt Gene Name: | CXXC5Â Â |
| UniProt Entry Name: | CXXC5_HUMAN |
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