The CXCR5 Polyclonal Antibody (CAB5268) is a valuable tool for researchers studying CXCR5, a chemokine receptor involved in immune cell migration and homing. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in techniques such as Western blotting.CXCR5 plays a crucial role in the immune response by regulating the movement of immune cells to lymphoid tissues, where they participate in the formation of germinal centers and the generation of antigen-specific immune responses. Dysregulation of CXCR5 signaling has been implicated in various diseases, including autoimmune disorders and cancer.
By binding specifically to the CXCR5 protein, this polyclonal antibody enables accurate detection and analysis of CXCR5 expression in various cell types. Its versatility makes it an ideal tool for research in immunology, oncology, and other fields where understanding immune cell migration and function is crucial. Further elucidating the role of CXCR5 in disease pathology may lead to the development of novel therapeutic strategies targeting this important chemokine receptor.
Product Name:
CXCR5 Rabbit Polyclonal Antibody
SKU:
CAB5268
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 273-372 of human CXCR5 (NP_001707.1).
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
643
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CXCR5 antibody (CAB5268) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
