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Anti-CXCR5 Antibody (CAB5268)

SKU:
CAB5268
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
  • Immunology Antibodies 2 Anti-CXCR5 Antibody CAB5268
  • Immunology Antibodies 2 Anti-CXCR5 Antibody CAB5268
€139 - €419
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Description

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Antibody Name:Anti-CXCR5 Antibody
Antibody SKU:CAB5268
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CXCR5 (NP_001707.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:B cells, BT-474, Raji, Mouse liver
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CXCR5 (NP_001707.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPVA ITMC EFLG LAHC CLNP MLYT FAGV KFRS DLSR LLTK LGCT GPAS LCQL FPSW RRSS LSES ENAT SLTT F
Gene ID:643
Uniprot:P32302
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:36kDa/41kDa
Observed MW:45kDa
Synonyms:CXCR5, BLR1, CD185, MDR15
Background:This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
UniProt Protein Function:CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:G-protein coupled receptor activity; protein binding; C-X-C chemokine receptor activity

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; B cell activation; immune response; cell motility; chemotaxis; lymph node development

NCBI Summary:This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Code:P32302
NCBI GenInfo Identifier:416718
NCBI Gene ID:643
NCBI Accession:P32302.1
UniProt Related Accession:P32302
Molecular Weight:
NCBI Full Name:C-X-C chemokine receptor type 5
NCBI Synonym Full Names:C-X-C motif chemokine receptor 5
NCBI Official Symbol:CXCR5  
NCBI Official Synonym Symbols:BLR1; CD185; MDR15  
NCBI Protein Information:C-X-C chemokine receptor type 5
UniProt Protein Name:C-X-C chemokine receptor type 5
UniProt Synonym Protein Names:Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD_antigen: CD185
UniProt Gene Name:CXCR5  
UniProt Entry Name:CXCR5_HUMAN
Anti-CXCR5 Antibody (CAB5268)Western blot analysis of extracts of various cell lines, using CXCR5 antibody (CAB5268) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-CXCR5 Antibody (CAB5268)Immunofluorescence analysis of U2OS cells using CXCR5 antibody (CAB5268) at dilution of 1:100. Blue: DAPI for nuclear staining.

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