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CXCR3 Polyclonal Antibody (CAB2939)

SKU:
CAB2939
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular
  • Cardiovascular Antibodies Anti-CXCR3 Antibody CAB2939
  • Cardiovascular Antibodies Anti-CXCR3 Antibody CAB2939
  • Cardiovascular Antibodies Anti-CXCR3 Antibody CAB2939
  • Cardiovascular Antibodies Anti-CXCR3 Antibody CAB2939
  • Cardiovascular Antibodies Anti-CXCR3 Antibody CAB2939
€129 - €359
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CXCR3 Polyclonal Antibody
SKU:CAB2939
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 289-368 of human CXCR3 (NP_001495.1).
Sequence:NCGR ESRV DVAK SVTS GLGY MHCC LNPL LYAF VGVK FRER MWML LLRL GCPN QRGL QRQP SSSR RDSS WSET SEAS YSGL
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:100
Synonyms:GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; CXCR3
Positive Sample:293T,K-562,HepG2,SGC996,SW620
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Multi-pass membrane protein.
Calculated MW:41kDa
Observed MW:44kDa

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).

Purification Method:Affinity purification
Gene ID:2833
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using CXCR3 Rabbit pAb (CAB2939) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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