null

CXCR3 Rabbit Polyclonal Antibody (CAB11601)

SKU:
CAB11601
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cardiovascular
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

CXCR3 Rabbit Polyclonal Antibody (CAB11601)

The CXCR3 Polyclonal Antibody (CAB11601) is a valuable tool for researchers studying the CXCR3 receptor, a key player in immune responses and inflammation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the CXCR3 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential reagent for studies in immunology and inflammatory diseases.CXCR3 is a chemokine receptor that plays a crucial role in directing immune cell trafficking to sites of inflammation, infection, and tumor growth.

Its involvement in these processes makes it a promising target for research into conditions such as autoimmune disorders, infectious diseases, and cancer. By understanding the function of CXCR3, researchers can develop targeted therapies that modulate immune responses and potentially improve treatment outcomes in these disease settings.

Product Name:CXCR3 Rabbit Polyclonal Antibody
SKU:CAB11601
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-53 of human CXCR3 (NP_001136269.1).
Sequence:MELR KYGP GRLA GTVI GGAA QSKS QTKS DSIT KEFL PGLY TAPS SPFP PSQV S
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; CXCR3
Positive Sample:U-937
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Multi-pass membrane protein.
Calculated MW:41kDa
Observed MW:46kDa

This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).

Purification Method:Affinity purification
Gene ID:2833
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from U-937 cells, using CXCR3 Rabbit pAb (CAB11601) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.

Related Products