The Anti-CXCR2 Antibody (CAB3301) is a valuable tool for researchers studying the CXCR2 receptor, a key molecule involved in inflammation and immune responses. This polyclonal antibody is raised in rabbits and is highly specific for human samples, making it ideal for use in various research applications, including Western blotting.CXCR2 is a chemokine receptor that plays a critical role in recruiting immune cells to sites of inflammation and infection. By targeting CXCR2, researchers can better understand the mechanisms behind inflammatory diseases, such as cancer, autoimmune disorders, and chronic inflammatory conditions.
The Anti-CXCR2 Antibody allows for the detection and analysis of CXCR2 expression in different cell types, offering insights into its function and potential therapeutic targets.Overall, the Anti-CXCR2 Antibody is a valuable tool for researchers looking to investigate the role of CXCR2 in immune regulation and inflammatory responses. Its specificity and reliability make it a key component in studies aimed at developing new treatments for a wide range of diseases and conditions.
Product Name:
CXCR2 Rabbit Polyclonal Antibody
SKU:
CAB3301
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 260-359 of human CXCR2 (NP_001548.1).
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
3579
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CXCR2 Rabbit pAb (CAB3301) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
