The CXCR1 Polyclonal Antibody (CAB16386) is a vital tool for researchers studying the CXCR1 protein, a chemokine receptor involved in inflammatory responses. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the CXCR1 protein, this antibody allows for the detection and analysis of CXCR1 in various cell types, making it ideal for studies in immunology and inflammation research.CXCR1, a key receptor for interleukin-8 (IL-8), plays a crucial role in recruiting neutrophils to sites of inflammation. Dysregulation of CXCR1 signaling has been implicated in various disease states, including cancer, autoimmune disorders, and inflammatory conditions.
Research on CXCR1 is essential for understanding the mechanisms of inflammation and developing targeted therapies to modulate inflammatory responses.By utilizing the CXCR1 Polyclonal Antibody, researchers can further explore the function and regulation of CXCR1, advancing our knowledge of immune responses and inflammatory processes. This antibody is a valuable tool for investigating the role of CXCR1 in health and disease, offering new insights into potential therapeutic strategies for various inflammatory conditions.
Product Name:
CXCR1 Rabbit Polyclonal Antibody
SKU:
CAB16386
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CXCR1 (NP_000625.1).
Sequence:
IFLL CWLP YNLV LLAD TLMR TQVI QESC ERRN NIGR ALDA TEIL GFLH SCLN PIIY AFIG QNFR HGFL KILA MHGL VSKE FLAR HRVT SYTS SSVN VSSN L
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.
Purification Method:
Affinity purification
Gene ID:
3577
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CXCR1 Rabbit pAb (CAB16386) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
