The CXCL11 Polyclonal Antibody (CAB6201) is a valuable tool for researchers studying the chemokine CXCL11, a key player in the immune response. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CXCL11 protein, this antibody enables the detection and analysis of CXCL11 in various cell types, making it ideal for studies in immunology and inflammatory conditions.CXCL11, also known as Interferon-inducible T-cell alpha chemoattractant (I-TAC), is involved in the recruitment and activation of immune cells during inflammatory responses.
Its role in regulating immune cell migration and activity makes it a crucial target for research into immune-mediated diseases, such as autoimmune disorders and chronic inflammatory conditions. Understanding the function of CXCL11 is essential for developing therapeutic strategies that target the immune response in these contexts.
Product Name:
CXCL11 Rabbit Polyclonal Antibody
SKU:
CAB6201
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-94 of human CXCL11 (NP_005400.1).
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6373
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat spleen using CXCL11 Rabbit pAb (CAB6201) at 1:1000 dilution incubated overnight at 4℃.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
