The CXCL10 Polyclonal Antibody (CAB19138) is specifically designed for researchers studying CXCL10, a chemokine protein involved in immune response and inflammation. This antibody, produced in rabbits, is highly sensitive and suitable for use in various experimental techniques, including Western blotting.CXCL10, also known as interferon-gamma-induced protein 10 (IP-10), is a key player in the recruitment and activation of immune cells at sites of infection or inflammation. Its upregulation is associated with various inflammatory conditions, making it a crucial target for research in immunology, infectious diseases, and autoimmune disorders.
The CXCL10 Polyclonal Antibody enables accurate detection and analysis of CXCL10 protein levels in different cell types, providing valuable insight into its role in disease pathogenesis.By utilizing this antibody, researchers can gain a better understanding of the molecular mechanisms underlying immune responses and potentially identify new therapeutic targets for conditions involving dysregulated inflammation. The CXCL10 Polyclonal Antibody is a versatile tool for advancing research in the fields of immunology and inflammation, ultimately contributing to the development of novel treatment strategies for a range of disorders.
Product Name:
CXCL10 Rabbit Polyclonal Antibody
SKU:
CAB19138
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-98 of human CXCL10/IP-10 (NP_001556.2).
Sequence:
VPLS RTVR CTCI SISN QPVN PRSL EKLE IIPA SQFC PRVE IIAT MKKK GEKR CLNP ESKA IKNL LKAV SKER SKRS P
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection.
Purification Method:
Affinity purification
Gene ID:
3627
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of THP-1, using CXCL10/IP-10 antibody (CAB19138) at 1:3000 dilution.THP-1 cells were treated by LPS for 6 hours,Brefeldin A for 3 hours and IFNγ (50ng/ml) for 8 hours of stimulation.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
