Cxcl1 Antibody (PACO32672)
- SKU:
- PACO32672
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Cxcl1 Antibody (PACO32672)
The CXCL1 Polyclonal Antibody (PAC032672) is a valuable tool for researchers studying the role of CXCL1, a member of the CXC chemokine family that plays a crucial role in inflammation and immune responses. This antibody, produced in rabbits, displays high reactivity towards human samples and has been validated for use in Western blot applications.By binding specifically to the CXCL1 protein, this antibody allows for accurate detection and analysis in various cell types, making it a versatile option for studies in immunology, inflammation, and cancer research.
CXCL1 is known for its involvement in the recruitment of neutrophils to sites of inflammation, as well as its potential role in tumor growth and metastasis.Understanding the function and regulation of CXCL1 is essential for uncovering its potential as a therapeutic target in various diseases, including cancer, inflammatory disorders, and autoimmune conditions. The CXCL1 Polyclonal Antibody provides researchers with a reliable tool to further explore the mechanisms by which CXCL1 influences immune responses and disease pathology.
| Antibody Name: | Cxcl1 Antibody (PACO32672) |
| Antibody SKU: | PACO32672 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Growth-regulated α protein (29-96AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation By similarity. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity. |
| Synonyms: | Growth-regulated α protein (C-X-C motif chemokine 1) (Platelet-derived growth factor-inducible protein KC) (Secretory protein N51) [Cleaved into: KC(5-72) (Hematopoietic synergistic factor) (HSF) (KC-T)], Cxcl1, Gro Gro1 Mgsa Scyb1 |
| UniProt Protein Function: | CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Cellular Component: extracellular space; cell; extracellular region; cytosol Molecular Function:growth factor activity; chemokine activity; CXCR chemokine receptor binding; cytokine activity Biological Process: neutrophil chemotaxis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to molecule of bacterial origin; positive regulation of superoxide release; positive regulation of potassium ion transport; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; inflammatory response; acute inflammatory response; regulation of cell proliferation |
| NCBI Summary: | This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013] |
| UniProt Code: | P12850 |
| NCBI GenInfo Identifier: | 121623 |
| NCBI Gene ID: | 14825 |
| NCBI Accession: | P12850.1 |
| UniProt Related Accession: | P12850 |
| Molecular Weight: | 10,254 Da |
| NCBI Full Name: | Growth-regulated alpha protein |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 1 |
| NCBI Official Symbol: | Cxcl1Â Â |
| NCBI Official Synonym Symbols: | KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1Â Â |
| NCBI Protein Information: | growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; alpha-chemokine; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC |
| UniProt Protein Name: | Growth-regulated alpha protein |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 1; Platelet-derived growth factor-inducible protein KC; Secretory protein N51Cleaved into the following chain:KC(5-72)Alternative name(s):Hematopoietic synergistic factor; HSF; KC-T |
| Protein Family: | KCNQ1 downstream neighbor protein |
| UniProt Gene Name: | Cxcl1Â Â |
| UniProt Entry Name: | GROA_MOUSE |
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