CUX1 Antibody (PACO58120)
- SKU:
- PACO58120
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CUX1 Antibody (PACO58120)
The CUX1 Polyclonal Antibody (PACO58120) is a valuable tool for researchers studying the CUX1 protein, a transcription factor with important roles in cell cycle regulation and development. This antibody, produced in rabbits, is specifically designed for use in various research applications, including Western blotting and immunohistochemistry.CUX1 is known for its involvement in diverse cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of CUX1 has been linked to cancer, making it a promising target for cancer research and therapy development.
The CUX1 Polyclonal Antibody enables precise detection and analysis of CUX1 expression in different cell types and tissues, facilitating investigations into its functions and mechanisms of action.Researchers studying gene regulation, cell biology, and cancer biology will find the CUX1 Polyclonal Antibody to be a valuable tool in their work. Its high reactivity with human samples and reliable performance in various experimental techniques make it a trusted reagent for advancing our understanding of the complex roles of CUX1 in health and disease.
| Antibody Name: | CUX1 Antibody (PACO58120) |
| Antibody SKU: | PACO58120 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:200-1:500 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Protein CASP protein (50-210AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: SH-SY5Y whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, Rat brain tissue, Rat liver tissue, Rat kidney tissue, Mouse brain tissue. All lanes: CUX1 antibody at 3.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 78, 73, 165, 162, 166, 154, 158, 148, 76 kDa. Observed band size: 78 kDa. |
 | IHC image of PACO58120 diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | May be involved in intra-Golgi retrograde transport. |
| Synonyms: | Protein CASP, CUX1, CUTL1 |
| UniProt Protein Function: | CUTL1 iso1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Membrane protein, integral; DNA-binding Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: cytosol; Golgi apparatus; nucleoplasm; nucleus Molecular Function:protein-tyrosine kinase activity; sequence-specific DNA binding Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] |
| UniProt Code: | Q13948 |
| NCBI GenInfo Identifier: | 85681028 |
| NCBI Gene ID: | 1523 |
| NCBI Accession: | Q13948.2 |
| UniProt Secondary Accession: | Q13948,Q53GU9, Q8TBS3, B3KWH3, B3KWH8, B4DZZ2, G3V1Z6 J3KPQ6, |
| UniProt Related Accession: | Q13948,P39880 |
| Molecular Weight: | 75,644 Da |
| NCBI Full Name: | Protein CASP |
| NCBI Synonym Full Names: | cut like homeobox 1 |
| NCBI Official Symbol: | CUX1Â Â |
| NCBI Official Synonym Symbols: | CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317Â Â |
| NCBI Protein Information: | protein CASP |
| UniProt Protein Name: | Protein CASP |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | CUX1Â Â |
| UniProt Entry Name: | CASP_HUMAN |
| Antibodies |
| CUX1 Antibody (PACO08681) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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