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CUX1 Antibody (PACO08681)

SKU:
PACO08681
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551
Frequently bought together:

Description

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CUX1 Antibody (PACO08681)

The CUX1 Polyclonal Antibody (PACO08681) is a valuable tool for researchers studying the CUX1 protein, a transcriptional regulator involved in various cellular processes, including cell proliferation and differentiation. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in immunohistochemistry and immunofluorescence applications.CUX1, also known as Cut Like Homeobox 1, is a critical player in gene regulation and has been implicated in cancer development and progression. By targeting the CUX1 protein, researchers can investigate its role in tumorigenesis and potentially identify new therapeutic strategies for cancer treatment.

The CUX1 Polyclonal Antibody enables the detection and analysis of CUX1 in different cellular contexts, making it an essential tool for studies in oncology and molecular biology.With its ability to specifically bind to the CUX1 protein, this antibody provides researchers with a powerful tool for investigating the mechanisms underlying CUX1-mediated cellular processes. Understanding the function of CUX1 is essential for advancing our knowledge of cancer biology and may lead to the development of novel targeted therapies for cancer patients.

Antibody Name:CUX1 Antibody (PACO08681)
Antibody SKU:PACO08681
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human CUX1
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:cut-like homeobox 1;CUX1;CASP;CDP;CDP/Cut;CDP1;COY1;CUTL1;CUX;Clox;Cux/CDP;GOLIM6;Nbla10317;p100;p110;p200;p75 ;
UniProt Protein Function:CUTL1 iso1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; Membrane protein, integral; DNA-binding

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: cytosol; Golgi apparatus; nucleoplasm; nucleus

Molecular Function:protein-tyrosine kinase activity; sequence-specific DNA binding

Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; regulation of transcription from RNA polymerase II promoter

NCBI Summary:The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
UniProt Code:Q13948
NCBI GenInfo Identifier:85681028
NCBI Gene ID:1523
NCBI Accession:Q13948.2
UniProt Secondary Accession:Q13948,Q53GU9, Q8TBS3, B3KWH3, B3KWH8, B4DZZ2, G3V1Z6 J3KPQ6,
UniProt Related Accession:Q13948,P39880
Molecular Weight:75,644 Da
NCBI Full Name:Protein CASP
NCBI Synonym Full Names:cut like homeobox 1
NCBI Official Symbol:CUX1  
NCBI Official Synonym Symbols:CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317  
NCBI Protein Information:protein CASP
UniProt Protein Name:Protein CASP
Protein Family:Homeobox protein
UniProt Gene Name:CUX1  
UniProt Entry Name:CASP_HUMAN

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