The Cullin4A Rabbit Monoclonal Antibody (CAB5064) is an essential tool for researchers studying Cullin4A, a key protein involved in the regulation of the cell cycle, DNA replication, and DNA repair processes. This monoclonal antibody, produced in rabbits, offers high specificity and sensitivity for detecting Cullin4A in various cell types and tissues.Cullin4A is a critical component of the Cullin-RING E3 ubiquitin ligase complex, which plays a crucial role in protein degradation and cell cycle control. Dysregulation of Cullin4A has been linked to various diseases, including cancer, making it a potential target for therapeutic interventions.
This antibody is validated for use in Western blot and immunofluorescence applications, providing researchers with valuable insights into the function and regulation of Cullin4A in cellular processes.By using the Cullin4A Rabbit Monoclonal Antibody (CAB5064), researchers can further explore the molecular mechanisms underlying Cullin4A-mediated pathways and its implications in disease development. This antibody is an indispensable tool for advancing our understanding of Cullin4A biology and potentially identifying novel therapeutic targets for the treatment of cancer and other related disorders.
Product Name:
Cullin 4A Rabbit Monoclonal Antibody
SKU:
CAB5064
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 660-759 of human Cullin 4A (Q13619).
CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).
Purification Method:
Affinity purification
Gene ID:
8451
Clone Number:
ARC1237
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cullin 4A Rabbit mAb (CAB5064) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
