The CUL7 Polyclonal Antibody (PAC014301) is a valuable tool for researchers studying the CUL7 protein, a key player in cellular processes such as protein degradation and cell cycle regulation. This antibody, raised in rabbits, is highly specific to human CUL7 and has been validated for use in Western blot applications. By binding to the CUL7 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for research in areas such as cell biology and cancer biology.CUL7 is a member of the Cullin family of proteins, which are involved in the assembly of E3 ubiquitin ligase complexes that target proteins for degradation.
Dysregulation of CUL7 has been implicated in various diseases, including cancer and developmental disorders. By studying the function of CUL7, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the CUL7 Polyclonal Antibody is a reliable tool for researchers looking to investigate the role of CUL7 in various cellular processes and disease pathways. Its high specificity and sensitivity make it a valuable asset for studies aimed at expanding our understanding of CUL7 function and its implications for human health.
Antibody Name:
CUL7 Antibody (PACO14301)
Antibody SKU:
PACO14301
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Rat
Immunogen:
Fusion protein of human CUL7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14301(CUL7 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:
cullin 7
UniProt Protein Function:
CUL7: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. Belongs to the cullin family.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; Golgi apparatus; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: ubiquitin-dependent protein catabolic process; viral reproduction; unfolded protein response; protein ubiquitination; microtubule cytoskeleton organization and biogenesis; positive regulation of dendrite morphogenesis; proteolysis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cytokinesis after mitosis; epithelial to mesenchymal transition; regulation of mitosis; vasculogenesis; Golgi organization and biogenesis; placenta developmentDisease: Three M Syndrome 1
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
