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CUL7 Antibody (PACO14300)

SKU:
PACO14300
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • CUL7 Antibody PACO14300
  • CUL7 Antibody PACO14300
€339

Description

system_update_altDatasheetsystem_update_altMSDS

CUL7 Antibody (PACO14300)

The CUL7 Antibody (PAC014300) is a polyclonal antibody designed for research involving CUL7, a protein that plays a crucial role in cellular processes such as cell cycle regulation and protein degradation. The antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the CUL7 protein, allowing for accurate detection and analysis in various cell types.CUL7 is a component of an E3 ubiquitin ligase complex that is involved in targeting proteins for degradation, making it a key player in maintaining cellular homeostasis.

Research on CUL7 is important in understanding its role in cell growth, division, and response to environmental stimuli. It is also implicated in diseases such as cancer and intellectual disability, making it a potential therapeutic target.By utilizing the CUL7 Antibody in research, scientists can further elucidate the functions and implications of CUL7 in various cellular processes. This antibody is a valuable tool for studies in molecular biology, oncology, and neurodevelopment.

Antibody Name:CUL7 Antibody (PACO14300)
Antibody SKU:PACO14300
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:Human, Rat
Immunogen:Fusion protein of human CUL7
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14300(CUL7 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14300(CUL7 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene.
Synonyms:cullin 7
UniProt Protein Function:CUL7: Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. Seems not to promote polyubiquitination and proteasomal degradation of TP53. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. Defects in CUL7 are the cause of 3M syndrome type 1 (3M1). An autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference, and normal intelligence and endocrine function. Skeletal changes include long slender tubular bones and tall vertebral bodies. Belongs to the cullin family.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; Golgi apparatus; centrosome; anaphase-promoting complex; perinuclear region of cytoplasm; cytoplasm; cytosol; nucleusMolecular Function: protein binding; ubiquitin protein ligase bindingBiological Process: ubiquitin-dependent protein catabolic process; viral reproduction; unfolded protein response; protein ubiquitination; microtubule cytoskeleton organization and biogenesis; positive regulation of dendrite morphogenesis; proteolysis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cytokinesis after mitosis; epithelial to mesenchymal transition; regulation of mitosis; vasculogenesis; Golgi organization and biogenesis; placenta developmentDisease: Three M Syndrome 1
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
UniProt Code:Q14999
NCBI GenInfo Identifier:21707140
NCBI Gene ID:9820
NCBI Accession:AAH33647
UniProt Secondary Accession:Q14999,Q5T654, B4DYZ0, F5H0L1
UniProt Related Accession:Q14999
Molecular Weight:199,750 Da
NCBI Full Name:Cullin 7
NCBI Synonym Full Names:cullin 7
NCBI Official Symbol:CUL7  
NCBI Official Synonym Symbols:3M1; KIAA0076; dJ20C7.5  
NCBI Protein Information:cullin-7
UniProt Protein Name:Cullin-7
UniProt Synonym Protein Names:
Protein Family:Cullin
UniProt Gene Name:CUL7  
UniProt Entry Name:CUL7_HUMAN
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