The CUL4B Polyclonal Antibody (CAB12696) is a crucial tool for researchers studying CUL4B, a protein involved in multiple cellular processes such as DNA repair, cell cycle regulation, and chromatin remodeling. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting CUL4B in human samples, making it a reliable tool for Western blot applications.CUL4B is a member of the cullin family of proteins and functions as a scaffold protein in the CUL4-RING E3 ubiquitin ligase complex, playing a key role in targeting specific substrate proteins for degradation. Dysregulation of CUL4B has been linked to various diseases, including cancer and neurodevelopmental disorders, highlighting the importance of studying its function and regulatory mechanisms.
By utilizing the CUL4B Polyclonal Antibody, researchers can gain valuable insights into the role of CUL4B in cellular processes and disease pathogenesis. This antibody enables the precise detection and analysis of CUL4B expression in different cell types, offering a versatile tool for investigations in molecular biology, cancer biology, and therapeutic development. Unlocking the mysteries of CUL4B function could provide new avenues for targeted therapies and precision medicine approaches in the future.
Product Name:
CUL4B Rabbit Polyclonal Antibody
SKU:
CAB12696
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human CUL4B (NP_003579.3).
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8450
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CUL4B Rabbit pAb (CAB12696) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
