The CTU1 Polyclonal Antibody (PAC021886) is a vital tool for researchers studying the CTU1 gene and its role in cellular processes. This high-quality antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CTU1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and genetic research.CTU1 is a key player in sulfur transfer pathways within the cell, essential for the biosynthesis of sulfur-containing molecules such as tRNA and iron-sulfur clusters.
Dysregulation of CTU1 has been implicated in various diseases, including cancer, neurodegeneration, and metabolic disorders. By gaining insights into the function of CTU1, researchers can uncover new therapeutic targets and develop innovative treatments for these conditions.Overall, the CTU1 Polyclonal Antibody is a valuable tool for scientists looking to unravel the complexities of sulfur metabolism and its implications for human health. Its high specificity and sensitivity make it an indispensable asset for furthering our understanding of CTU1 biology and its therapeutic potential.
Antibody Name:
CTU1 Antibody (PACO21886)
Antibody SKU:
PACO21886
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from C-terminal of human ATBP3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Beausoleil S.A., Nat. Biotechnol. 24:1285-1292(2006).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from LOVO cells, using ATBP3 antibody.
Synonyms:
Cancer-associated gene protein; ATP-binding domain-containing protein 3; ATPBD3;
UniProt Protein Function:
ATPBD3: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.Protein type: EC 2.7.7.-Chromosomal Location of Human Ortholog: 19q13.41Cellular Component: mitochondrion; cytosolMolecular Function: protein binding; nucleotidyltransferase activity; tRNA bindingBiological Process: tRNA wobble uridine modification; protein urmylation
