The CTU1 Polyclonal Antibody (PACO05668) is a valuable tool for researchers studying the CTU1 protein, involved in the process of tRNA modification. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CTU1 protein, researchers can effectively detect and analyze its expression in various cell types, making it an essential component for studies in molecular biology and RNA processing.CTU1 plays a crucial role in maintaining the integrity of tRNA molecules, ensuring proper translation of genetic information in the cell.
Dysregulation of CTU1 activity has been implicated in various diseases, including neurodegenerative disorders and cancer. By investigating the function of CTU1, researchers can gain valuable insights into these pathologies and potentially develop targeted therapies to address them. The CTU1 Polyclonal Antibody is a valuable tool for advancing our understanding of tRNA modification and its implications in human health.
Antibody Name:
CTU1 Antibody (PACO05668)
Antibody SKU:
PACO05668
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human ATPBD3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CTU1; ATPBD3; NCS6; Cytoplasmic tRNA 2-thiolation protein 1; ATP-binding domain-containing protein 3; Cancer-associated gene protein; Cytoplasmic tRNA adenylyltransferase 1
UniProt Protein Function:
ATPBD3: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.Protein type: EC 2.7.7.-Chromosomal Location of Human Ortholog: 19q13.41Cellular Component: mitochondrion; cytosolMolecular Function: protein binding; nucleotidyltransferase activity; tRNA bindingBiological Process: tRNA wobble uridine modification; protein urmylation
