Cortactin Rabbit Polyclonal Antibody (CAB5795)
- SKU:
- CAB5795
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Cortactin Rabbit Polyclonal Antibody |
SKU: | CAB5795 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 301-400 of human Cortactin (NP_005222.2). |
Sequence: | DYSK GFGG KYGV QKDR MDKN ASTF EDVT QVSS AYQK TVPV EAVT SKTS NIRA NFEN LAKE KEQE DRRK AEAE RAQR MAKE RQEQ EEAR RKLE EQAR AKTQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | EMS1; Cortactin |
Positive Sample: | HeLa,U-937(negative control sample),Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Membrane, Peripheral membrane protein, cell cortex, clathrin-coated pit, cytoskeleton, dendrite, dendritic spine, focal adhesion, lamellipodium, podosome, ruffle. |
Calculated MW: | 62kDa |
Observed MW: | 80kDa |
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2017 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |