The CTTN Polyclonal Antibody (CAB15054) is a valuable tool for researchers studying CTTN, a protein involved in cell migration and invasion processes. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the CTTN protein, this antibody allows for the detection and analysis of CTTN expression in different cell types, making it an essential component for studies in cancer research and cell biology.CTTN, also known as cortactin, plays a crucial role in the regulation of actin polymerization and cytoskeletal rearrangements, which are important for cell motility and invasion.
Dysregulation of CTTN has been linked to cancer progression and metastasis, making it a promising target for therapeutic interventions. Understanding the function and expression of CTTN is essential for developing strategies to target cancer cells that rely on CTTN-mediated processes.Overall, the CTTN Polyclonal Antibody is a reliable tool for researchers interested in investigating the role of CTTN in cancer biology and cell migration. Its high reactivity, specificity, and validation make it a valuable asset for exploring the mechanisms underlying cancer progression and identifying potential therapeutic targets.
Product Name:
Cortactin Rabbit Polyclonal Antibody
SKU:
CAB15054
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Cortactin (NP_612632.1).
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
2017
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cortactin Rabbit pAb (CAB15054) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
