Cortactin Rabbit Polyclonal Antibody (CAB15054)
- SKU:
- CAB15054
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | Cortactin Rabbit Polyclonal Antibody |
SKU: | CAB15054 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Cortactin (NP_612632.1). |
Sequence: | MWKA SAGH AVSI AQDD AGAD DWET DPDF VNDV SEKE QRWG AKTV QGSG HQEH INIH KLRE NVFQ EHQT LKEK ELET GPKA SHGY GGKF GVEQ DRMD KSAV GHEY QSKL SKHC SQVD SVRG FGGK FGVQ MDRV DQSA VGFE YQGK TEKH ASQK DYSS GFGG KYGV QADR VDKS AVGF DYQG KTEK HESQ RDYS KGFG GKYG |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | EMS1; Cortactin |
Positive Sample: | MCF7,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Membrane, Peripheral membrane protein, cell cortex, clathrin-coated pit, cytoskeleton, dendrite, dendritic spine, focal adhesion, lamellipodium, podosome, ruffle. |
Calculated MW: | 62kDa |
Observed MW: | 85kDa |
This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2017 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |