The CTSD Polyclonal Antibody (CAB13292) is a valuable tool for research involving cathepsin D (CTSD), a lysosomal aspartyl protease involved in various cellular processes. This antibody, produced in rabbits, is highly specific for recognizing CTSD in human samples and is ideal for use in Western blotting applications. By binding to CTSD, researchers can detect and study the expression of this protein in different cell types, making it beneficial for studies in areas such as cell biology, metabolism, and neurodegenerative diseases.
CTSD is known for its role in protein degradation and processing, as well as its involvement in autophagy, apoptosis, and cell death pathways. Dysregulation of CTSD has been implicated in various diseases, including cancer, Alzheimer's disease, and cardiovascular disorders. Therefore, investigating the function and regulation of CTSD is essential for understanding its contribution to these pathological conditions and for developing potential therapeutic strategies targeting CTSD activity.
Product Name:
Cathepsin D Rabbit Polyclonal Antibody
SKU:
CAB13292
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-249 of human Cathepsin D (NP_001900.1).
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
1509
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SK-BR-3 cells, using Cathepsin D Rabbit pAb (CAB13292) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
