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CTSD Monoclonal Antibody [P4G2AT] (CPAB0130)

SKU:
CPAB0130
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
P4G2AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

CTSD Monoclonal Antibody [P4G2AT] (CPAB0130)

The CTSD Polyclonal Antibody (CPAB0130) is specifically designed for research involving CTSD, a lysosomal protein involved in the degradation of intracellular proteins. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It targets the CTSD protein, allowing for detection and analysis in various cell types, making it ideal for studies in lysosomal biology and neurodegenerative diseases.CTSD, also known as cathepsin D, plays a crucial role in the regulation of intracellular protein degradation and maintenance of cellular homeostasis. Dysregulation of CTSD has been linked to various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease.

Research into the function and regulation of CTSD is essential for developing potential therapeutic interventions targeting lysosomal dysfunction in these diseases.Overall, the CTSD Polyclonal Antibody is a valuable tool for researchers studying lysosomal biology, neurodegenerative disorders, and other conditions involving intracellular protein degradation pathways. Its high reactivity and specificity make it a reliable option for Western blot experiments aimed at characterizing the expression and activity of CTSD in different cellular contexts.

Product Name:CTSD Antibody
Product Sku:CPAB0130
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CTSD mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CTSD amino acids 21-412 purified from Ecoli.
Clone:P4G2AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:CTSD antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.
Synonyms:Cathepsin D, EC 3.4.23.5, CTSD, CPSD, CLN10, MGC2311.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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