The CTSC Polyclonal Antibody (CAB8403) is designed for research involving the CTSC protein, a lysosomal protease implicated in various cellular processes, particularly in immune regulation and inflammation. The antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blot. By specifically binding to the CTSC protein, researchers can detect and analyze its expression in different cell types, making it an invaluable tool for studies in immunology, inflammation, and infectious diseases.CTSC, also known as Cathepsin C, plays a crucial role in the activation of serine proteases involved in immune cell function and host defense.
Dysregulation of CTSC has been linked to various pathological conditions, including autoimmune diseases, inflammatory disorders, and infectious diseases. Investigating the function of CTSC is essential for understanding its role in disease pathology and developing targeted therapies to modulate immune responses. Unlocking the potential of CTSC in immune regulation could lead to innovative approaches in treating a wide range of immune-related disorders.
Product Name:
CTSC Rabbit Polyclonal Antibody
SKU:
CAB8403
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-134 of human CTSC (NP_001805.3).
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Purification Method:
Affinity purification
Gene ID:
1075
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CTSC Rabbit pAb (CAB8403) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
