CTSC Rabbit Polyclonal Antibody (CAB8403)
- SKU:
- CAB8403
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | CTSC Rabbit Polyclonal Antibody |
SKU: | CAB8403 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-134 of human CTSC (NP_001805.3). |
Sequence: | DTPA NCTY LDLL GTWV FQVG SSGS QRDV NCSV MGPQ EKKV VVYL QKLD TAYD DLGN SGHF TIIY NQGF EIVL NDYK WFAF FKYK EEGS KVTT YCNE TMTG WVHD VLGR NW |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 |
Synonyms: | JP; HMS; JPD; PLS; CPPI; DPP1; DPPI; PALS; DPP-I; PDON1; CTSC |
Positive Sample: | HeLa,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Lysosome. |
Calculated MW: | 15kDa/16kDa/52kDa |
Observed MW: | 13kDa/64kDa |
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.
Purification Method: | Affinity purification |
Gene ID: | 1075 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |