CTRB1 Rabbit Polyclonal Antibody (CAB15043)
- SKU:
- CAB15043
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | CTRB1 Rabbit Polyclonal Antibody |
SKU: | CAB15043 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 79-263 of human CTRB1 (NP_001897.4). |
Sequence: | RTSD VVVA GEFD QGSD EENI QVLK IAKV FKNP KFSI LTVN NDIT LLKL ATPA RFSQ TVSA VCLP SADD DFPA GTLC ATTG WGKT KYNA NKTP DKLQ QAAL PLLS NAEC KKSW GRRI TDVM ICAG ASGV SSCM GDSG GPLV CQKD GAWT LVGI VSWG SDTC STSS PGVY ARVT KLIP WVQK ILAA N |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 IF/ICC,1:50 - 1:100 |
Synonyms: | CTRB; CTRB1 |
Positive Sample: | Mouse spleen,Mouse stomach |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular space. |
Calculated MW: | 28kDa |
Observed MW: | 28kDa |
This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 in intron 1 of the CTRB2 gene is diagnostic for this inversion. This CTRB1 gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein.
Purification Method: | Affinity purification |
Gene ID: | 1504 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |