The CTRB1 Polyclonal Antibody (CAB15043) is a valuable tool for researchers studying CTRB1, a protease enzyme involved in various biological processes, including digestion and regulation of inflammatory responses. This antibody, produced using rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the CTRB1 protein, this antibody allows for the detection and analysis of CTRB1 expression in different cell types, making it a versatile option for studies in molecular biology and disease mechanisms.CTRB1, also known as chymotrypsin-like elastase family member 2A, plays a crucial role in protein digestion and has been implicated in the pathogenesis of pancreatic diseases, such as pancreatitis and pancreatic cancer.
Understanding the function and regulation of CTRB1 is essential for unraveling its contribution to these diseases and may lead to the development of targeted therapies that modulate CTRB1 activity. Researchers interested in exploring the role of CTRB1 in health and disease will find this antibody to be a valuable asset in their experimental toolbox.
Product Name:
CTRB1 Rabbit Polyclonal Antibody
SKU:
CAB15043
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 79-263 of human CTRB1 (NP_001897.4).
This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB1 gene is located head-to-head with the related CTRB2 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 in intron 1 of the CTRB2 gene is diagnostic for this inversion. This CTRB1 gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein.
Purification Method:
Affinity purification
Gene ID:
1504
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CTRB1 Rabbit pAb (CAB15043) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
