CTLA4 Rabbit Polyclonal Antibody (CAB13965)
- SKU:
- CAB13965
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | CTLA4 Rabbit Polyclonal Antibody |
SKU: | CAB13965 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-223 of human CD152/CTLA-4 (NP_005205.2). |
Sequence: | SSRG IASF VCEY ASPG KATE VRVT VLRQ ADSQ VTEV CAAT YMMG NELT FLDD SICT GTSS GNQV NLTI QGLR AMDT GLYI CKVE LMYP PPYY LGIG NGTQ IYVI DPEP CPDS DFLL WILA AVSS GLFF YSFL LTAV SLSK MLKK RSPL TTGV YVKM PPTE PECE KQFQ PYFI PIN |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; CD152/CTLA-4 |
Positive Sample: | Mouse lung,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Single-pass type I membrane protein. |
Calculated MW: | 25kDa |
Observed MW: | 36kDa |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Purification Method: | Affinity purification |
Gene ID: | 1493 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |