The CTDSP2 Polyclonal Antibody (PACO08655) is a valuable tool for researchers interested in studying CTDSP2, a protein involved in the regulation of cellular processes such as gene expression and cell growth. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot assays. By targeting the CTDSP2 protein, this antibody allows for the detection and analysis of CTDSP2 in various cell types, making it an essential tool for studies in molecular biology and cancer research.CTDSP2, also known as C-terminal domain small phosphatase 2, plays a crucial role in the modulation of signaling pathways involved in cell proliferation and differentiation.
Understanding the function of CTDSP2 is essential for unraveling its role in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. The CTDSP2 Polyclonal Antibody provides researchers with a powerful tool to investigate the function of CTDSP2 in various biological processes, paving the way for the development of targeted therapies and diagnostic tools.
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2;CTDSP2;OS4;PSR2;SCP2 ;
UniProt Protein Function:
CTDSP2: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.Protein type: Nuclear receptor co-regulator; EC 3.1.3.16; PhosphataseChromosomal Location of Human Ortholog: 12q14.1Cellular Component: nucleoplasmMolecular Function: protein binding; metal ion binding; CTD phosphatase activityBiological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; negative regulation of protein amino acid phosphorylation; unfolded protein response; protein amino acid dephosphorylation
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
NCBI Synonym Full Names:
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
NCBI Official Symbol:
CTDSP2Â Â
NCBI Official Synonym Symbols:
OS4; PSR2; SCP2Â Â
NCBI Protein Information:
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; NLI-interacting factor 2; conserved gene amplified in osteosarcoma; nuclear LIM interactor-interacting factor 2; protein OS-4; small C-terminal domain phosphatase 2; small CTD phosphatase 2
UniProt Protein Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2
UniProt Synonym Protein Names:
Nuclear LIM interactor-interacting factor 2; NLI-interacting factor 2; Protein OS-4; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2; SCP2
Protein Family:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase
