UniProt Protein Function: | CTDSP2: Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.Protein type: Nuclear receptor co-regulator; EC 3.1.3.16; PhosphataseChromosomal Location of Human Ortholog: 12q14.1Cellular Component: nucleoplasmMolecular Function: protein binding; metal ion binding; CTD phosphatase activityBiological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; negative regulation of protein amino acid phosphorylation; unfolded protein response; protein amino acid dephosphorylation |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | O14595 |
NCBI GenInfo Identifier: | 55584145 |
NCBI Gene ID: | 10106 |
NCBI Accession: | O14595.2 |
UniProt Secondary Accession: | O14595,Q53ZR2, Q6NZY3, Q9UEX1, A8K5H4 |
UniProt Related Accession: | O14595 |
Molecular Weight: | |
NCBI Full Name: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 |
NCBI Synonym Full Names: | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 |
NCBI Official Symbol: | CTDSP2Â Â |
NCBI Official Synonym Symbols: | OS4; PSR2; SCP2Â Â |
NCBI Protein Information: | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; NLI-interacting factor 2; conserved gene amplified in osteosarcoma; nuclear LIM interactor-interacting factor 2; protein OS-4; small C-terminal domain phosphatase 2; small CTD phosphatase 2 |
UniProt Protein Name: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 |
UniProt Synonym Protein Names: | Nuclear LIM interactor-interacting factor 2; NLI-interacting factor 2; Protein OS-4; Small C-terminal domain phosphatase 2; Small CTD phosphatase 2; SCP2 |
Protein Family: | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase |
UniProt Gene Name: | CTDSP2Â Â |
UniProt Entry Name: | CTDS2_HUMAN |