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CTCF Polyclonal Antibody

SKU:
CAB21337
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
$167 - $635
Frequently bought together:

Description

CTCF Polyclonal Antibody (CAB21337)

The CTCF Polyclonal Antibody (AB10024) is a valuable tool for researchers studying the CTCF protein, a key regulator of gene expression and chromatin organization. This antibody, produced in rabbits, has been validated for use in a variety of applications such as immunohistochemistry and chromatin immunoprecipitation. It specifically targets the CTCF protein, allowing for precise detection and analysis in different experimental settings.CTCF is a versatile protein that plays a crucial role in various biological processes, including transcriptional regulation, DNA looping, and genomic imprinting. Its involvement in these mechanisms makes it a key player in gene expression and genome stability.

Researchers studying epigenetics, gene regulation, and stem cell biology will find the CTCF Polyclonal Antibody invaluable for their experiments.By using the CTCF Polyclonal Antibody, researchers can gain valuable insights into the function and localization of the CTCF protein in different cell types and tissues. This antibody is a reliable tool for advancing our understanding of gene regulation and chromatin architecture, with implications for various fields of study including cancer research, developmental biology, and epigenetics.

Product Name:CTCF Polyclonal Antibody
Product Code:CAB21337
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:100-1:500, IHC-P 1:50-1:200, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:293T
Cellular Location:Chromosome, Nucleus, centromere, nucleoplasm

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_006556.1).
Sequence:MEGDA VEAIV EESET FIKGK ERKTY QRRRE GGQEE DACHL PQNQT DGGEV VQDVN SSVQM VMMEQ LDPTL LQMKT EVMEG TVAPE AEAAV DDTQI ITLQV VNMEE QPINI GELQL VQVPV PVTVP VATTS VEELQ GAYEN EVSKE GLAES EPMIC HTLPL PEGFQ VVKVG ANGEV ETLEQ GELPP QEDPS WQKDP DYQPP AKKTK KTKKS KLRYT EEGKD VDVSV YDFEE EQQEG LLSEV NAEKV VGNMK PPKPT KIKKK
Synonyms:MRD21, FAP108, CFAP108
Calculated MW:83kDa
Observed MW:140kDa

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