The CTBS Polyclonal Antibody (PACO08652) is a valuable tool for researchers studying cathepsin B, a lysosomal cysteine protease involved in various cellular processes, including protein degradation and antigen processing. This antibody, produced in rabbits, exhibits high specificity for detecting cathepsin B in human samples and is validated for use in various applications, such as Western blot and immunohistochemistry.Cathepsin B is a key player in cancer progression, inflammation, and neurodegenerative diseases.
Its dysregulation has been linked to tumor growth, metastasis, and resistance to chemotherapy, making it an attractive target for therapeutic intervention. By utilizing the CTBS Polyclonal Antibody, researchers can gain insights into the role of cathepsin B in disease pathogenesis and potentially identify new treatment strategies aimed at targeting this protease.
CTBS: Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase. Belongs to the glycosyl hydrolase 18 family.Protein type: EC 3.2.1.-; HydrolaseChromosomal Location of Human Ortholog: 1p22Cellular Component: extracellular spaceMolecular Function: chitin binding; chitinase activityBiological Process: chitin catabolic process
UniProt Protein Details:
NCBI Summary:
Chitobiase is a lysosomal glycosidase involved in degradation of asparagine-linked oligosaccharides on glycoproteins (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov 2010]
