The CTBP2 Polyclonal Antibody (CAB0463) is a valuable tool for researchers studying CTBP2, a transcriptional corepressor involved in gene regulation and cellular processes. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding to CTBP2 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in molecular biology and cancer biology.CTBP2, also known as C-terminal binding protein 2, is known for its role in transcriptional regulation and its involvement in tumor progression and metastasis.
Understanding the functions of CTBP2 is crucial for unraveling its impact on gene expression and cellular pathways, providing insights into cancer development and progression. By targeting CTBP2, researchers can uncover potential therapeutic strategies for combating cancer and other diseases related to dysregulated gene expression.Overall, the CTBP2 Polyclonal Antibody (CAB0463) offers a reliable tool for studying CTBP2 and its implications in various biological processes, opening avenues for further research and potential therapeutic interventions.
Product Name:
CTBP2 Rabbit Monoclonal Antibody
SKU:
CAB0463
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 346-445 of human CTBP2 (P56545).
WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
CTBP2; C-terminal-binding protein 2
Positive Sample:
HeLa,NIH/3T3,Rat testis
Conjugate:
Unconjugated
Cellular Localization:
Cell junction, Nucleus, synapse.
Calculated MW:
49kDa
Observed MW:
47kDa
This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1488
Clone Number:
ARC2509
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CTBP2 Rabbit mAb (CAB0463) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
