The CSTB Polyclonal Antibody is a valuable tool for researchers studying CSTB, a protein involved in various cellular processes including regulation of immune responses and cell survival. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications, enabling reliable detection and analysis of CSTB levels in different cell types.CSTB, also known as cystatin B, is a potent inhibitor of cysteine proteases and plays a crucial role in regulating protease activity within cells. Dysregulation of CSTB has been implicated in various diseases, making it an important target for research in fields such as neurology, oncology, and immunology.
By studying the function and regulation of CSTB, researchers can gain insights into the underlying mechanisms of diseases and potentially develop targeted therapies for conditions associated with CSTB dysfunction.Overall, the CSTB Polyclonal Antibody offers a powerful tool for investigating the biological role of CSTB and its potential implications in disease pathogenesis. Its high specificity and reliability make it a valuable asset for researchers looking to advance their understanding of CSTB-related processes and develop innovative therapeutic strategies.
Product Name:
CSTB Polyclonal Antibody
SKU:
CAB21370
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-98 of human CSTB (NP_000091.1).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies.
Purification Method:
Affinity purification
Gene ID:
1476
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CSTB Rabbit pAb (CAB21370) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
