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CSTA Monoclonal Antibody [PAT1B12AT] (CPAB0657)

SKU:
CPAB0657
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT1B12AT
Applications:
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

CSTA Monoclonal Antibody [PAT1B12AT] (CPAB0657)

The CSTA Polyclonal Antibody (CPAB0657) is a valuable tool for researchers studying CSTA, a protein involved in various cellular processes, including regulating protease activity and cell adhesion. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting and immunohistochemistry applications.CSTA, also known as Cystatin A, is a member of the cystatin superfamily and is known to inhibit cysteine proteases, such as cathepsins. Its role in controlling protease activity makes it a key player in processes like tissue remodeling, wound healing, and immune response modulation.

Additionally, CSTA has been implicated in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions.By using the CSTA Polyclonal Antibody, researchers can gain valuable insights into the functions and regulation of CSTA in various biological contexts. Whether studying protein expression levels in different cell types or investigating CSTA's involvement in disease progression, this antibody is an essential tool for advancing our understanding of this important protein.

Product Name:CSTA Antibody
Product Sku:CPAB0657
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CSTA mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CSTA protein 1-98 amino acids purified from Ecoli.
Clone:PAT1B12AT.
Reactivity:Other bodies
Applications:ELISA, Flow Cytometry
Purification Method:CSTA antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:Cystatin-A is the intracellular inhibitor of cysteine proteinase cathepsin B (CatB) and belongs to family 1 of the cystatin superfamily of inhibitor proteins. CSTA is a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. It has been proposed that extracellular CatB together with other classes of proteinases are all subjected to a cascade-like manner of activation. CatB and its inhibitor Cystatin-A are involved in degradation of extracellular matrix proteins during tissue remodeling. CSTA is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Cystatin-A has been reported to be found in high concentrations in epithelial cells, polymorphonuclear leukocytes and lymphoid tissue. Stefins may be used as prognostic and diagnostic tools for cancer.
Synonyms:Cystatin-A, Cystatin-AS, Stefin-A, CSTA, STF1, STFA.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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