The Cystatin 8 Polyclonal Antibody (CAB1224) is a valuable tool for research involving Cystatin 8, a protein involved in regulating cysteine protease activity and potentially playing a role in various diseases and conditions. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for Western blot applications.Cystatin 8, a member of the cystatin superfamily, is known for its ability to inhibit cysteine proteases, enzymes involved in various physiological processes including protein degradation and immune response. Dysregulation of cysteine proteases has been linked to diseases such as cancer, neurodegenerative disorders, and inflammatory conditions, highlighting the importance of studying proteins like Cystatin 8.
By utilizing the Cystatin 8 Polyclonal Antibody, researchers can effectively detect and analyze the expression of Cystatin 8 in different cell types and tissues, providing insights into its role in disease pathology and potential therapeutic strategies. This antibody is a valuable tool for studies in immunology, cancer research, and other fields where understanding cysteine protease regulation is essential.
Product Name:
CST8 Rabbit Polyclonal Antibody
SKU:
CAB1224
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 53-142 of human CST8 (NP_005483.1).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The encoded protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10047
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CST8 antibody (CAB1224) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
