The CST11 Polyclonal Antibody (PAC042150) is a valuable tool for researchers investigating CST11, a crucial protein involved in various cellular functions. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the CST11 protein, researchers can effectively detect and analyze its expression in different cell types, making it ideal for studies in immunology, oncology, and cell biology.CST11, also known as Cystatin 11, plays a key role in regulating protease activity and maintaining cellular homeostasis.
Its dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders. By studying CST11, researchers can gain insights into disease mechanisms and potentially identify novel therapeutic targets for intervention.Overall, the CST11 Polyclonal Antibody is a powerful tool for researchers looking to explore the molecular pathways involving CST11 and its implications in disease development. Its high specificity and reliability make it a valuable asset in advancing research in the fields of cancer biology, neuroscience, and beyond.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO42150 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO42150 at dilution of 1:100.
Background:
Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.
Synonyms:
Cystatin-11, CST11, CST8L
UniProt Protein Function:
CST11: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 20p11.21Cellular Component: cytoplasm; nucleusMolecular Function: cysteine protease inhibitor activityBiological Process: defense response to bacterium
UniProt Protein Details:
NCBI Summary:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]
