The CST11 Polyclonal Antibody (PACO00674) is a valuable tool for researchers studying CST11, a protein involved in immune regulation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting assays. By targeting the CST11 protein, this antibody allows for precise detection and analysis of CST11 in various cell types, making it ideal for investigations in fields such as immunology and cancer research.CST11, also known as a crucial immune regulator, plays a vital role in maintaining immune balance by modulating inflammatory responses and suppressing allergic reactions.
Its importance in immune system modulation makes CST11 a promising target for studies related to diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CST11 is essential for the development of new therapies aimed at manipulating immune responses in these disease contexts.
Antibody Name:
CST11 Antibody
Antibody SKU:
PACO00674
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human Cystatin 11.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
CST11; CST8L; Cystatin-11
UniProt Protein Function:
CST11: Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 20p11.21Cellular Component: cytoplasm; nucleusMolecular Function: cysteine protease inhibitor activityBiological Process: defense response to bacterium
UniProt Protein Details:
NCBI Summary:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein shown to have antimicrobial activity against E. coli. Alternative splicing yields two variants encoding distinct isoforms. [provided by RefSeq, Sep 2014]
