The Cystatin SN Polyclonal Antibody (CAB6570) is an essential tool for researchers studying Cystatin SN, a protein involved in regulating cysteine protease activity and maintaining the balance of protease inhibitors in the body. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.Cystatin SN is known for its role in inhibiting multiple cysteine proteases, which play key roles in various physiological processes such as apoptosis, protein digestion, and immune response. Dysregulation of cysteine proteases is linked to various diseases including cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting Cystatin SN, researchers can gain insights into the mechanisms underlying these conditions and identify potential therapeutic strategies.This antibody enables the detection and analysis of Cystatin SN in a wide range of cell types, making it a valuable tool for studies in biochemistry, molecular biology, and medical research. Understanding the function of Cystatin SN is crucial for advancing our knowledge of protease regulation and developing targeted therapies for diseases driven by protease dysregulation.
Product Name:
CST1 Rabbit Polyclonal Antibody
SKU:
CAB6570
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-141 of human CST1 (NP_001889.2).
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid.
Purification Method:
Affinity purification
Gene ID:
1469
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CST1 Antibody (CAB6570) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
