The CSPP1 Polyclonal Antibody (CAB9983) is a valuable tool for researchers studying CSPP1, a protein involved in various cellular processes including cell division and cytoskeletal organization. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the CSPP1 protein, allowing for detection and analysis in different cell types, making it ideal for studies in cell biology and cancer research.CSPP1, also known as centrosome and spindle pole-associated protein 1, plays a crucial role in mitotic spindle organization and chromosome segregation during cell division.
Dysregulation of CSPP1 has been implicated in cancer progression and other diseases, highlighting its importance as a potential therapeutic target. By elucidating the function of CSPP1, researchers can gain insights into the molecular mechanisms underlying disease pathology and develop targeted treatment strategies.
Product Name:
CSPP1 Rabbit Polyclonal Antibody
SKU:
CAB9983
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 962-1221 of human CSPP1 (NP_079066.5).
Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle, spindle pole.
Calculated MW:
146kDa
Observed MW:
145kDa
This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
79848
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CSPP1 antibody (CAB9983) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
