CSNK2A3 Antibody (PACO61999)
- SKU:
- PACO61999
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IP
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CSNK2A3 Antibody (PACO61999)
The CSNK2A3 Polyclonal Antibody (PAC061999) is a valuable tool for researchers studying CSNK2A3, a protein kinase implicated in various cellular processes. This antibody, generated in rabbits, exhibits high specificity for human samples and is optimized for detection in Western blot applications. By targeting the CSNK2A3 protein, researchers can analyze its expression and activity in different cell types, providing insights into its role in cancer biology and other diseases.CSNK2A3, also known as casein kinase 2 alpha 3, plays a crucial role in regulating cell growth, proliferation, and survival pathways.
Its dysregulation has been linked to cancer development and progression, making it a promising target for therapeutic interventions. By studying the function of CSNK2A3, researchers can uncover novel treatment strategies for cancer and other diseases associated with aberrant kinase activity.Overall, the CSNK2A3 Polyclonal Antibody is a valuable tool for investigating the functional significance of CSNK2A3 in various cellular processes and disease states. Its high reactivity and specificity make it an essential reagent for advancing research in cancer biology and kinase signaling pathways.
| Antibody Name: | CSNK2A3 Antibody (PACO61999) |
| Antibody SKU: | PACO61999 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IP |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:200-1:500, IP:1:200-1:2000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Casein kinase II subunit α 3 protein (151-391AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: PC3 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate, Hela whole cell lysate, THP-1 whole cell lysate. All lanes: CSNK2A3 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46 kDa. Observed band size: 46 kDa. |
 | Immunoprecipitating CSNK2A3 in Hela whole cell lysate. Lane 1: Rabbit control IgG instead of PACO61999 in Hela whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/50000). Lane 2: PACO61999 (5µg) + Hela whole cell lysate (0.5mg). Lane 3: Hela whole cell lysate (20µg). |
 | IHC image of PACO61999 diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acid, c residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. |
| Synonyms: | Casein kinase II subunit α 3 (CK II α 3) (EC 2.7.11.1) (Casein kinase II α 1 polypeptide pseudogene), CSNK2A3, CSNK2A1P |
| UniProt Protein Function: | CSNK2A3: Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down- regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). Interacts with PMLProtein type: Oncoprotein; EC 2.7.11.1Chromosomal Location of Human Ortholog: 11p15.3 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q8NEV1 |
| NCBI GenInfo Identifier: | 487524482 |
| NCBI Gene ID: | 283106 |
| NCBI Accession: | Q8NEV1.2 |
| UniProt Secondary Accession: | Q8NEV1 |
| UniProt Related Accession: | Q8NEV1 |
| Molecular Weight: | 45,220 Da |
| NCBI Full Name: | Casein kinase II subunit alpha 3 |
| NCBI Synonym Full Names: | casein kinase 2 alpha 3 |
| NCBI Official Symbol: | CSNK2A3Â Â |
| NCBI Official Synonym Symbols: | CSNK2A1PÂ Â |
| NCBI Protein Information: | casein kinase 2, alpha 1 polypeptide-like |
| UniProt Protein Name: | Casein kinase II subunit alpha 3 |
| UniProt Synonym Protein Names: | Casein kinase II alpha 1 polypeptide pseudogene |
| Protein Family: | Casein kinase |
| UniProt Gene Name: | CSNK2A3Â Â |
| UniProt Entry Name: | CSK23_HUMAN |
Related Products
HNR Antibody Antibody (CAB17497)
€139 - €419
Anti-CD47 Biotinylated Recombinant Antibody Antibody (HDLA014)
€1,012
Anti-CTLA4 Biotinylated Recombinant Antibody Antibody (HDLA015)
€1,012