The CSNK1A1 Polyclonal Antibody (CAB16225) is an essential tool for researchers studying CSNK1A1, a key player in various cellular processes including cell division, DNA repair, and circadian rhythms. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting CSNK1A1 in human samples, making it suitable for Western blot applications.CSNK1A1, also known as casein kinase 1 alpha 1, is a serine/threonine kinase that regulates the phosphorylation of numerous proteins involved in cell signaling pathways. Dysregulation of CSNK1A1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions.
Thus, studying the expression and activity of CSNK1A1 is crucial for understanding its role in disease development and progression.By utilizing the CSNK1A1 Polyclonal Antibody, researchers can delve deeper into the mechanisms through which CSNK1A1 modulates cellular functions and explore its potential as a therapeutic target. This antibody enables precise detection and analysis of CSNK1A1 in a variety of cell types, making it a valuable tool for investigations in molecular biology, cancer research, and drug discovery.
Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis.
Purification Method:
Affinity purification
Gene ID:
1452
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Casein Kinase 1 alpha (CSNK1A1) Rabbit pAb (CAB16225) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
