The CSMD1 Polyclonal Antibody (PAC019522) is a valuable tool for researchers studying the CSMD1 protein, a cell surface molecule with implications in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. Its ability to bind specifically to CSMD1 enables precise detection and analysis in a range of cell types, making it a versatile choice for immunology and cancer research studies.
CSMD1, also known as CUB and Sushi Multiple Domains 1, is known to play a role in cell adhesion, signal transduction, and immune regulation. Its involvement in these key processes positions it as a target of interest in research related to cancer, autoimmune diseases, and inflammatory conditions. By gaining a better understanding of the function of CSMD1, researchers can potentially uncover new therapeutic targets for addressing these complex health conditions.
Antibody Name:
CSMD1 Antibody (PACO19522)
Antibody SKU:
PACO19522
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human CSMD1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19522(CSMD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19522(CSMD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
CSMD1 CUB and Sushi multiple domains 1 is a protein that in humans is encoded by the CSMD1gene. It is a potential tumour suppressor, the deletion of which may result in head and neck carcinomas behaving more aggressively. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas.
Synonyms:
CUB and Sushi multiple domains 1
UniProt Protein Function:
CSMD1: Potential suppressor of squamous cell carcinomas. Belongs to the CSMD family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 8p23.2Cellular Component: integral to membrane
