CSK Rabbit Polyclonal Antibody (CAB16824)
- SKU:
- CAB16824
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | CSK Rabbit Polyclonal Antibody |
SKU: | CAB16824 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 188-450 of human CSK (NP_004374.1). |
Sequence: | WALN MKEL KLLQ TIGK GEFG DVML GDYR GNKV AVKC IKND ATAQ AFLA EASV MTQL RHSN LVQL LGVI VEEK GGLY IVTE YMAK GSLV DYLR SRGR SVLG GDCL LKFS LDVC EAME YLEG NNFV HRDL AARN VLVS EDNV AKVS DFGL TKEA SSTQ DTGK LPVK WTAP EALR EKKF STKS DVWS FGIL LWEI YSFG RVPY PRIP LKDV VPRV EKGY KMDA PDGC PPAV YEVM KNCW HLDA AMRP SFLQ LREQ LEHI KTHE LHL |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CSK |
Positive Sample: | U-87MG,Mouse spleen |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 51kDa |
Observed MW: | 50kDa |
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1445 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |