The CSK Polyclonal Antibody (CAB16824) is a valuable tool for researchers studying CSK, a protein tyrosine kinase involved in various signaling pathways. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it an ideal choice for Western blot applications. By binding to CSK, this antibody enables the detection and analysis of the protein in different cell types, allowing for the investigation of its role in cellular signaling and disease processes.CSK is known to play a crucial role in the regulation of cell proliferation, differentiation, and apoptosis.
Dysregulation of CSK has been implicated in various diseases, including cancer and autoimmune disorders. By studying the function of CSK using this antibody, researchers can gain valuable insights into its role in these diseases and potentially identify new therapeutic targets for intervention.Overall, the CSK Polyclonal Antibody (CAB16824) is a reliable tool for researchers looking to investigate the role of CSK in cellular signaling pathways and disease processes. Its high specificity and reactivity make it a valuable asset for studies in cancer biology, immunology, and beyond.
Product Name:
CSK Rabbit Polyclonal Antibody
SKU:
CAB16824
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 188-450 of human CSK (NP_004374.1).
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1445
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CSK Rabbit pAb (CAB16824) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
